In 2025, the topic of weight and appetite control became one of the hottest in the world of medicine and nutraceuticals.
Products affecting GLP-1 (glucagon-like peptide-1) receptors have gained significant popularity.
This hormone, produced in the intestine, plays a key role in regulating appetite, glucose levels, and gastric emptying rate.
Alongside pharmacotherapy, the field of nutraceutical support for GLP-1 is actively developing.
Recent studies presented at Vitafoods Europe 2025 and Natural Products Expo show that certain nutrients and ingredients can stimulate GLP-1 secretion or mimic its effects.
This opens the way for safe, natural appetite control.
GLP-1: How Does This Mechanism Work?
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GLP-1 is released in the intestine after eating.
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It slows stomach emptying → creating a feeling of fullness.
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Increases insulin sensitivity → stabilizing glucose levels.
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Acts on appetite centers in the brain → reducing the desire to overeat.
Nutraceutical Solutions to Stimulate GLP-1
Researchers are studying different groups of substances:
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Soluble fibers (psyllium, glucomannan, β-glucans) — during fermentation, they produce short-chain fatty acids that stimulate GLP-1 secretion.
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Proteins and peptides — certain amino acids (L-glutamine, glycine) enhance incretin production.
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Polyphenols (blueberries, green tea, cocoa) — influence the microbiome and satiety hormones.
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Probiotics and postbiotics — certain strains (Bifidobacterium animalis, Lactobacillus plantarum) are associated with increased GLP-1 levels.
Table 1. Nutrients Affecting GLP-1
| Group | Examples | Potential Effect |
|---|---|---|
| Soluble fibers | Psyllium, glucomannan, β-glucans | Increase satiety, reduce appetite |
| Proteins and peptides | L-glutamine, glycine, dairy peptides | Stimulate GLP-1 secretion |
| Polyphenols | Blueberries, green tea, grapes | Modulate microbiome, satiety hormones |
| Probiotics/Postbiotics | B. animalis, L. plantarum | Enhance incretin response |
Practical Application in 2025
Modern nutraceutical products combine several ingredients at once:
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Fibers + probiotics — synbiotics that enhance GLP-1 production.
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Protein bars with polyphenols — snacks that simultaneously satiate and stimulate satiety hormones.
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Functional drinks with postbiotics — a new trend presented at Vitafoods.
Table 2. Practical Use of Nutrients in Appetite Control
| Situation | Solution | Additional Advice |
|---|---|---|
| Excess weight | Fibers + probiotics | Add to breakfast and dinner |
| Frequent snacking | Protein bars with polyphenols | Monitor calorie balance |
| Insulin resistance | Fibers + postbiotics | Glucose level control |
| Active sports | Protein drinks | Consume after workout |
| After 40 years | Combined formulas | Pair with Mediterranean diet |
FAQ — Frequently Asked Questions
1. Can nutraceuticals replace GLP-1 drugs?
No. They can serve as a preventive or supportive tool but do not replace pharmacotherapy.
2. When is the best time to take fibers for appetite control?
20–30 minutes before meals with a glass of water.
3. Are there risks of side effects?
Bloating or discomfort may occur at high fiber doses — gradual introduction is recommended.
Conclusion
GLP-1 is a key hormone regulating appetite. While pharmacological drugs remain effective for obesity treatment, nutraceutical solutions provide a safe and accessible way to support weight control without drugs.
Fibers, proteins, polyphenols, and probiotics can become an important part of a strategy for maintaining health in a busy urban lifestyle.
References
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Drucker DJ. Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Cell Metab. 2018.
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Tolhurst G. et al. Short-chain fatty acids stimulate GLP-1 secretion. Diabetes. 2012.
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Chambers ES. et al. Effects of glutamine and dietary fibers on GLP-1. Am J Clin Nutr. 2015.
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Jayasinghe TN. et al. Probiotics and GLP-1 modulation. Nutrients. 2020.
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Vitafoods Europe 2025 Innovation Report. Trends in appetite regulation and nutraceuticals.
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