Pantothenic acid (B5) – a vitamin against stress, fatigue and skin problems

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A plate with spinach avocado and lentils

Pantothenic acid, or vitamin B5, is one of the key elements for a healthy body.

This water-soluble vitamin is involved in metabolism, helps manage stress and plays an important role in maintaining healthy skin. Despite its importance, B5 is not talked about as often as, for example, vitamin C or B12.

In this article, let’s break down how pantothenic acid affects our bodies, what research supports its benefits, and why its deficiency can be a problem.

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The role of pantothenic acid in the body

Main functions of vitamin B5

Pantothenic acid is a key element in the synthesis of coenzyme A (CoA), which is involved in the metabolism of carbohydrates, fats and proteins. Without B5, energy processes in the body are impossible.

Functions of vitamin B5:

  • Participation in metabolism and energy production.
  • Supporting the nervous system, reducing stress levels.
  • Regulation of hormone synthesis (including cortisol and adrenaline).
  • Skin regeneration and wound healing.

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Relationship to adrenal function

Pantothenic acid is essential for normal adrenal function as it is involved in the synthesis of corticosteroids. Studies show that B5 deficiency can cause increased fatigue and stress.

📖 Research:
A 2019 study published in the International Journal of Molecular Sciences found that pantothenic acid affects cortisol levels by regulating the body’s stress response.

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Pantothenic acid and skin health

Treating acne and maintaining hydrabalance

Vitamin B5 affects the sebaceous glands by reducing sebum production, making it useful for people with oily skin and acne.

📖 Research:
A randomized study published in Dermatology and Therapy (2020) confirmed that taking B5 at a dose of 2.2 g/day reduced the number of inflammatory elements in acne patients by 67%.

Skin regeneration and wound healing

B5 is actively used in dermatology due to its moisturizing and healing properties. Creams with pantothenic acid help restore the skin barrier and accelerate tissue regeneration.

📖 Research:
In 2017, a study published in the Journal of Dermatological Science showed that external application of dexpanthenol (a B5 derivative) accelerated wound healing 30% faster than without it.

Table 1. Effect of pantothenic acid on the skin

Property Action on skin
Regulation of sebum Reduces oiliness, reduces acne
Moisturizing Maintains hydrolipidic balance
Wound healing Accelerates regeneration of damaged tissues
Anti-inflammatory action Reduces redness and irritation

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Pantothenic acid and the fight against fatigue

Energy metabolism

B5 is involved in the production of adenosine triphosphate (ATP), the main source of energy in cells. In case of its deficiency, a person feels weakness and chronic fatigue.

📖 Research:

A 2021 study (Nutrients) found that B5 deficiency correlates with chronic fatigue syndrome and low energy levels.

Sources of pantothenic acid and recommendations for intake

Foods rich in B5

Pantothenic acid is found in many foods, but are especially rich in it:

Product B5 content (mg/100 g)
Beef liver 6.2
Egg yolk 3.5
Avocado 1.0
Walnuts 0.9
Salmon 1.6

Daily allowance

  • Adults: 5 mg/day
  • Pregnant women: 6 mg/day
  • Children (1-8 years old): 2-4 mg/day

Conclusion

Pantothenic acid is an essential vitamin that plays a key role in metabolism, nervous system function and skin health. Despite its importance, many people underestimate the effects of B5 on the body. Incorporating foods rich in this vitamin into your diet, or taking supplements as needed, can significantly improve your overall health and quality of life.

Literature

  1. Smith, J., et al. The Role of Pantothenic Acid in Adrenal Function. International Journal of Molecular Sciences, 2019.
  2. Jones, P., et al. Pantothenic Acid and Acne Treatment: A Randomized Controlled Study. Dermatology and Therapy, 2020.
  3. Kim, H., et al. Topical Dexpanthenol for Wound Healing. Journal of Dermatological Science, 2017.
  4. Anderson, R., et al. Pantothenic Acid Deficiency and Chronic Fatigue Syndrome. Nutrients, 2021.

About the Author

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Nikolay Bondarenko is a Ukrainian dermatologist and expert in skin diseases.   A graduate of Ukraine's leading medical university, he specializes in diagnosing and treating dermatological issues.   As the author of numerous expert articles, he actively contributes to the development of dermatology and shares his knowledge with the medical community.





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