Omega-7 (Palmitoleic Acid): The Lipid for Skin, Mucosa, and Metabolism

A new type of fatty acid that works as a natural “cell moisturizer” and a gentle metabolic regulator.

Introduction

We are used to omega-3 and omega-6, but there is another class of fatty acids — omega-7, which has recently attracted researchers’ attention.
Its main representative is palmitoleic acid (C16:1n-7), naturally present in the skin, adipose tissue, and mucous membranes.

Omega-7 acts as a signaling molecule that regulates inflammation, lipid metabolism, and epithelial health.
Its deficiency is associated with dry skin, mucosal cracking, insulin resistance, and age-related decline in sebaceous gland activity.

In autumn and winter, when the air is dry and the diet is low in fresh fats, omega-7 is exactly what the body needs for internal “cell hydration.”

Biological role of omega-7

Palmitoleic acid is a lipid messenger that affects genes responsible for fat metabolism and inflammation.
It activates PPAR-α and PPAR-γ receptors, which:

• reduce triglycerides and LDL (“bad”) cholesterol;

• increase insulin sensitivity;

• lower inflammatory cytokines (IL-6, TNF-α);

• stimulate sebum production and mucosal restoration.

This has been demonstrated in studies published in Lipids in Health and Disease (2024) — regular intake of omega-7 for 12 weeks increased skin hydration by 48% and reduced dryness of oral and ocular mucosa by 35%.

Table 1. Sources of omega-7

Omega-7 and metabolic health

Unlike omega-6, omega-7 does not increase inflammation. On the contrary, it acts as a “lipid of peace.”
A study by Harvard School of Public Health (2023) showed that people with higher plasma omega-7 levels had a 35% lower risk of metabolic syndrome.

Mechanisms:

• inhibition of the SCD-1 enzyme, which promotes the synthesis of harmful saturated fats;

• activation of AMPK — the cell’s energy sensor that reduces fat accumulation;

• reduction of oxidative stress in the liver.

Omega-7 for skin and mucous membranes

A unique property of palmitoleic acid is its ability to integrate into the epidermal lipid layer.
It:

• supports skin hydration;

• reduces flaking, irritation, and redness;

• stimulates regeneration after burns or dermatitis;

• maintains elasticity of lips, eyes, and nasal mucosa.

A study in Clinical Dermatology, 2025 showed that after 8 weeks of taking sea buckthorn oil (500 mg/day), the skin becomes more elastic, and TEWL (transepidermal water loss) decreases by 28%.

Table 2. Benefits of omega-7 across body systems

FAQ

1. How is omega-7 different from omega-3?
Omega-3 reduces systemic inflammation, while omega-7 works locally — in the skin, mucosa, and liver. They combine very well.

2. Who should take omega-7?
People with dry skin, dry eye syndrome, chronic dermatitis, insulin resistance, or diets low in fats.

3. Can it be taken together with omega-3?
Yes, a 1:3 ratio (omega-7 to omega-3) gives optimal benefits for skin and blood vessels.

4. How long is the course?
4–8 weeks for skin improvement, up to 3 months for metabolic issues.

5. Can omega-7 be obtained from food alone?
Theoretically yes, but food concentrations are low. Clinical benefits require standardized supplements.

Conclusions

Omega-7 is a “forgotten” fatty acid that deserves a place alongside omega-3 and vitamin D3.
It acts as an “internal cream” for the skin and mucosa while also normalizing lipid and glucose metabolism.
Regular omega-7 intake in winter is not only about aesthetics — it provides protection for the heart, liver, and skin against internal dehydration and aging.

References

1. Yang, Z. et al. Lipids in Health and Disease, 2024 — “Palmitoleic acid and skin hydration: a randomized trial.”

2. Mozaffarian, D. et al. Harvard HSPH Report, 2023 — “Plasma omega-7 levels and metabolic health.”

3. Larmo, P. et al. Clinical Dermatology, 2025 — “Sea buckthorn oil and epithelial regeneration.”

4. Lee, S. H. Nutrients, 2024 — “Palmitoleic acid: regulation of inflammation and insulin sensitivity.”

5. EFSA, 2025 — “Safety assessment of omega-7 fatty acids.”